Science Curriculum Vitae: Chloé E. Atreya
Publications
Atreya, C.E. and Anderson, K.S. (2004) Kinetic characterization of bifunctional
thymidylate synthase-dihydrofolate reductase (TS-DHFR) from cryptosporidium
hominis: A paradigm shift for TS activity and channeling behavior. Journal of
Biological Chemistry, 279, 18, 18314-22
Atreya, C.E., Johnson, E.F., Williamson, J., Chang, S-Y, Liang, P-H, and Anderson,
K.S. (2003) Probing Electrostatic Channeling in Protozoal Bifunctional Thymidylate
Synthase-Dihydrofolate Reductase Using Site-Directed Mutagenesis. Journal of
Biological Chemistry, 278, 28901-11
Atreya, C.E., Johnson, E.F., Irwin, J. I., Dow, A., Massimine, K.M., Coppens,
I.,
Stempliuk, V., Beverley, S., Joiner, K.A., Shoichet, B.K., and Anderson, K.S.
(2003) A Molecular Docking Strategy Identifies Eosin B as a Non-Active Site
Inhibitor of Protozoal Bifunctional Thymidylate Synthase-Dihydrofolate Reductase.
Journal of Biological Chemistry, 278, 14092-100
Johnson, E.F, Hinz, W, Atreya C.E., Maley, F. and Anderson, K.S. (2002) Mechanistic
Characterization of T. gondii Thymidylate Synthase-Dihydrofolate Reductase:
Evidence for a TS Intermediate and TS Half-Sites Reactivity. Journal of Biological
Chemistry, 277, 43126-36
Morgan, C.J., Gelfand, M., Atreya, C.E., and Miranker, A.D. (2001) Kidney Dialysis-
associated Amyloidosis: A Molecular Role for Copper in Fiber Formation. Journal
of Molecular Biology, 309, 339-345
Education and Research
Residency, Internal Medicine, University of Washington, Seattle
MD, Yale University School
of Medicine, 2005
PhD in Pharmacology, Yale University School of Medicine, 2004. Dissertation
entitled: “Mechanistic and Structure-Function Analysis of Thymidylate
Synthase-Dihydrofolate Reductase from Protozoal Parasites: Implications for
the Development of Non-Active Site Inhibitors.” Dr. Karen S. Anderson,
Advisor
BA in Molecular Biology, Princeton University, 1998. Undergraduate Senior Thesis
entitled: “Covalent Inhibition of Protein Tyrosine Kinases Containing
Engineered Cysteines.” Dr. Kevan Shokat, Advisor
Research intern in cardiovascular gene therapy with Dr. Elizabeth Nabel, University
of Michigan Medical Center, 1995 Howard Hughes Summer Internships with Dr. Francis
Collins, Human Genome Center, University of Michigan, 1993 and 1992
Teaching and Presentations
Teaching Assistant, Yale Investigative Medicine Program course in Structure-Based
Drug Design, 2002, 2003
“A Molecular Docking Strategy Identifies a Non-Active Site Inhibitor of
Protozoal
Bifunctional Thymidylate Synthase-Dihydrofolate Reductase” was presented
at the following conferences: Drugs Against Tropical Protozoan Parasites: Target
Selection, Structural Biology, and Rational Medicinal Chemistry, Keystone, Colorado,
2002; Yale Chemical Biology Symposium, Yale Department of Chemistry, 2002; Student
Research Day, Yale School of Medicine, 2002